| Equinix | Redwood City | 22 de junho de 1998 |
| ESPN, LLC | Bristol | 7 de setembro de 1979 |
| Ethyl Corporation | Richmond | 1921 |
| Everlast | Nova Iorque | 1910 |
| Exelon | Chicago | 2000 |
| Exidy | Sunnyvale | 1974 |
| Expeditors International | Seattle | 1979 |
| Exxon | Las Colinas | 1 de janeiro de 1973 |
| Eye-Fi | Mountain View | 2005 |
| FactSet | Norwalk | 1978 |
| Fairmont Hotels & Resorts | Toronto | 1907 |
| Fannie Mae | Noroeste de Washington, D.C. | 1938 |
| Fantasy Flight Games | Roseville | 1995 |
| Feastables | Chicago | abril 2021 |
| FedEx | Memphis | 1971 |
| Fenty Beauty | 425 Market Street | 8 de setembro de 2018 |
| Fidelity National Information Services | — | 1 de fevereiro de 2006 |
| Firebase | São Francisco | 2010 |
| FireEye | Milpitas | fevereiro 2004 |
| First Republic Bank | São Francisco | 5 de fevereiro de 1985 |
| Fiserv | Brookfield | 1984 |
| Fitbit | São Francisco | 2007 |
| Folgers | Nova Orleães | 1850 |
| Ford Racing | Dearborn | — |
| Forrester Research | Cambridge | 1983 |
| Fox 2000 Pictures | Century City | 7 de janeiro de 1994 |
| Fox Sports | Los Angeles | 12 de agosto de 1994 |
| Franklin Templeton Investments | San Mateo | 1947 |
| Freddie Mac | McLean | 1970 |
| Frederator Studios | Nova Iorque | 1997 |
| Fresh Del Monte Produce | Coral Gables | 1886 |
| Frigidaire | Charlotte | 1918 |
| Fruit of the Loom | Bowling Green | 1851 |
| Fry's Electronics | São José | 1985 |
| Funny or Die | San Mateo | 12 de abril de 2007 |
| Fusion-io | Cottonwood Heights | 2006 |
| Future Shop | Burnaby | 1982 |
| Galoob | South San Francisco | 1957 |
| GameStop | Grapevine | 20 de agosto de 1980 |
| Gannett Company | Tysons Corner, Nova Iorque | 6 de outubro de 1906 |
| Gap | São Francisco | 1969 |
| Gateway | Irvine | 1 de setembro de 1985 |
| Gathering of Developers | Texas | janeiro 1998 |
| GE Healthcare | Chicago | 2004 |
| General American Transportation Corporation | Chicago | 1933 |
| General Atomics | San Diego | 1955 |
| General Dynamics Electric Boat | Groton | 1899 |
| General Foods | Nova Iorque | 1929 |