| Delta Air Lines | Atlanta | 17 de junho de 1929 |
| Depositphotos | Fort Lauderdale | 4 de novembro de 2009 |
| Detroit Electric Car Company | Detroit | 1907 |
| Devon Energy | Oklahoma City | 1971 |
| Diamond Multimedia | Los Angeles | 1982 |
| Dick's Sporting Goods | Coraopolis | 1948 |
| Dickies | Fort Worth | 1918 |
| Digidesign | Daly City | 1984 |
| Digital Eclipse | Califórnia | 7 de agosto de 1992 |
| Digital Photography Review | — | 1998 |
| DigitalGlobe | Westminster | 1992 |
| DigitalOcean | Nova Iorque | agosto 2011 |
| Diller Scofidio + Renfro | — | 1981 |
| Disney Music Group | Burbank | 1998 |
| Disney-ABC Domestic Television | Burbank | 1983 |
| Dodge | Dodge Building | 14 de dezembro de 1900 |
| Dodge & Cox | São Francisco | 1930 |
| Dolby Laboratories | São Francisco | 1965 |
| Dollar General | Goodlettsville | 1939 |
| Dominion Energy | Richmond | 1983 |
| Doyle Dane Bernbach | Chicago, São Francisco, Londres | 1949 |
| Dr Pepper Snapple Group | Plano | 7 de maio de 2008 |
| Dr. Scholl's | Chicago, Londres | 1906 |
| Dremel | Racine | 1932 |
| Dunkin' Donuts | Canton, Quincy | 1950 |
| Dunlop Manufacturing | Benicia | 1965 |
| Duracell | Chicago, Bethel | 1930 |
| Dynetics | Huntsville | 1974 |
| EA Sports | Burnaby | 1991 |
| Eastman Kodak | Rochester, Nova Iorque | 1882 |
| Eataly | Monticello d'Alba | 2010 |
| Eazel | Mountain View | 1999 |
| EBSCO Information Services | Birmingham | 1943 |
| Eckert-Mauchly Computer Corporation | Filadélfia | 1948 |
| Eckō Unlimited | East Brunswick | 1993 |
| Eclipse Comics | Forestville, Staten Island | 1977 |
| Ecolab | Saint Paul | 1923 |
| Edmodo | San Mateo | 1 de setembro de 2008 |
| Eldeman | Nova Iorque | 1952 |
| Eli Lilly and Company | Indianápolis | 1901 |
| Elliott Management Corporation | Nova Iorque | 1977 |
| Embarcadero Technologies | Austin | outubro 1993 |
| EMC Corporation | Hopkinton | agosto 1979 |
| Emerson Electric | St. Louis | 24 de setembro de 1890 |
| EMG | Santa Rosa | 1976 |
| Encyclopædia Britannica, Inc. | Chicago | 1768 |
| Energizer | St. Louis | 2000 |
| Enron | Houston | 1985 |