| Snowflake Inc. | San Mateo | 2012 |
| Sociedade de Criação de Língua | Garden Grove | 2007 |
| SolarCity | San Mateo, Califórnia | 2006 |
| Sonos | Santa Bárbara | 2002 |
| Sony Music | Nova Iorque | 1 de janeiro de 2009 |
| Sony Pictures Motion Picture Group | Culver City | 1998 |
| Southern Company | Atlanta | 1945 |
| Southern Pacific Railroad | São Francisco | 1865 |
| Spanx | Atlanta | 2000 |
| Spectravideo | — | 1981 |
| Speedway Motorsports | Concord | 1959 |
| Standard Oil Company | Ohio, Cleveland, Nova Iorque | 1890 |
| Standard Oil of Ohio | Cleveland | 1911 |
| Stanley Black & Decker | New Britain | 1843 |
| Starkey Hearing Technologies | Eden Prairie | 1967 |
| State Farm Insurance | Bloomington | 1922 |
| State Street Corporation | Boston | 1792 |
| Steelcase | Grand Rapids | 1912 |
| Steinway Musical Instruments | Waltham | 1995 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Storage Technology Corporation | Louisville | 1969 |
| Stripe | São Francisco, South San Francisco | 2010 |
| Studebaker | South Bend | 1852 |
| Stüssy, Inc. | Irvine | 1980 |
| Substack | — | 29 de novembro de 2017 |
| Sunoco | Dallas | 1886 |
| Supermicro | São José | 1993 |
| Supreme | Nova Iorque | abril 1994 |
| SurveyMonkey | San Mateo | 1999 |
| Swift Engineering | San Clemente | 1983 |
| Symbolics | Concord | 1979 |
| Synaptics | Santa Clara | 1986 |
| Synopsys | Mountain View | 1986 |
| Sysco | Houston | 1969 |
| T-Mobile US | Bellevue | 2001 |
| T. Rowe Price | Baltimore | 1937 |
| Tandem Computers | Cupertino | 1974 |
| TASCAM | Tóquio | 1971 |
| TaylorMade Golf Company | Carlsbad | 1979 |
| TBWA Worldwide | Nova Iorque | 1970 |
| Tektronix | Beaverton | 1946 |
| Tenneco | Lake Forest | 1930 |
| TerraPower | Bellevue | 2008 |
| Tesla | Austin | 1 de julho de 2003 |
| Tesla Energy | Fremont | — |
| Texaco | San Ramon | 1901 |
| The Athletic | São Francisco | janeiro 2016 |
| The Babylon Bee | Jupiter | 1 de março de 2016 |