| Rocketdyne | Los Angeles | 1955 |
| Rogers Locomotive and Machine Works | — | 1832 |
| Rohm and Haas | Filadélfia | 1 de setembro de 1909 |
| Roku | Los Gatos | outubro 2002 |
| Room to Read | São Francisco | 2000 |
| Rotten Tomatoes | São Francisco | 19 de agosto de 1998 |
| Roxio | Santa Clara | 2001 |
| RR Donnelley | Chicago | 1864 |
| Ryan Aeronautical Company | San Diego | 1934 |
| Ryder | Coral Gables | 1933 |
| S&P Global | Rockefeller Center, Nova Iorque | — |
| S. C. Johnson & Son | Racine | 1886 |
| Saatchi & Saatchi | Nova Iorque | 1970 |
| Saks Fifth Avenue | Nova Iorque | 1898 |
| San Diego Football Club | San Diego | 18 de maio de 2023 |
| Sanmina-SCI | São José | 1980 |
| Santa Cruz Operation | Santa Cruz | 1979 |
| Schlumberger | Houston | 1926 |
| Scholastic Corporation | Nova Iorque, Scholastic Building | 1920 |
| Schweizer Aircraft Corporation | Horseheads, Nova Iorque | 1939 |
| SDI Media Group | Culver City | 1965 |
| Seabourn Cruise Line | Seattle, Miami | 1986 |
| Seagate Technology | Cupertino | 1979 |
| Seattle Computer Products | Seattle | 1979 |
| Seattle's Best Coffee | Seattle | 1991 |
| SeaWorld | Orlando | 21 de março de 1964 |
| Sequential Circuits | São José | 1970 |
| Seymour Duncan | Goleta | 1978 |
| Shelby SuperCars | West Richland | 1999 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Sherwin-Williams | Cleveland | 1866 |
| Shield AI | San Diego | 28 de maio de 2015 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Showtime | Nova Iorque | 1983 |
| Shutterstock | Nova Iorque, Empire State Building | 2003 |
| Silicon Graphics | Sunnyvale, Mountain View | 9 de novembro de 1981 |
| Silicon Laboratories | Austin | 1996 |
| Silver Lake | Menlo Park | 1999 |
| Sirius Satellite Radio | Nova Iorque | 17 de maio de 1990 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | 1 de julho de 2024 |
| Skechers | Manhattan Beach | 1992 |
| Skybound Entertainment | Beverly Hills | 1992 |
| Skydance Media | Hollywood | 2006 |
| Skywalker Sound | Lucas Valley | 1975 |
| Smith & Wesson | Springfield | 1852 |
| Snap-on | Kenosha | 1920 |