| Powell Peralta | — | 1978 |
| Powell's Books | Portland | 1971 |
| Powerset | São Francisco | 2005 |
| Pratt & Whitney | East Hartford | 1925 |
| Precision Manuals Development Group | Alexandria | 1997 |
| Prince Sports | Bordentown | 1970 |
| Proactiv Solution | — | 1995 |
| Product Red | Nova Iorque | 2006 |
| Prometheus Global Media | Nova Iorque | 2009 |
| Providence Equity Partners | 50 Kennedy Plaza | 1989 |
| PRS Guitars | Stevensville | 1985 |
| PVH Corp. | Nova Iorque | 1881 |
| Qorvo | Greensboro | 2015 |
| Quaker Oats | Chicago | 1877 |
| Qualcomm | San Diego | julho 1985 |
| Qualtrics | Provo | 2002 |
| Quest Software | Aliso Viejo | 1987 |
| Quiksilver | Huntington Beach | 1969 |
| Quora | Mountain View | 21 de junho de 2010 |
| QVC | Düsseldorf | 1986 |
| R. J. Reynolds Tobacco Company | Winston-Salem | 1874 |
| Radisson Hotel Group | Minnetonka | 1962 |
| Rainforest Cafe | Houston | 1994 |
| Raising Cane's Chicken Fingers | Baton Rouge | 1996 |
| Ralph Lauren (marca) | Nova Iorque | 1967 |
| Ralston Purina | St. Louis | 1894 |
| Ramada | Phoenix | 1953 |
| Rambus | Sunnyvale | 1990 |
| Rasmussen Reports | Asbury Park | 2003 |
| Rawlings | Town and Country | 1887 |
| Rayovac | Middleton | 1906 |
| RC4WD | São Francisco | 2001 |
| Real3D | Orlando | 1986 |
| Red Ventures | Charlotte, Fort Mill, Indian Land | 2000 |
| Redback Networks | São José | 1996 |
| Redfin | Seattle | 2004 |
| Remington Arms | Madison | 1816 |
| Remington Rand | Buffalo, Nova Iorque | 1927 |
| REO Motor Car Company | Lansing | 1905 |
| Republic Airways Holdings | Indianápolis | 1973 |
| Revlon | Nova Iorque | 1932 |
| Revolution Studios | Los Angeles | 2000 |
| Ring of Honor | — | 2002 |
| Rite Aid | Filadélfia, East Pennsboro Township | 1962 |
| RKO Pictures | Manhattan | 23 de outubro de 1928 |
| Robinhood | Palo Alto | 2013 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Roblox Corporation | San Mateo | 2004 |