| AM General | South Bend | 1971 |
| American Austin Car Company | Butler, Delaware | 1929 |
| Baker Motor Vehicle | Cleveland | 1899 |
| Cadillac | Detroit | 1902 |
| Chalmers Automobile | Detroit | 1908 |
| Checker Motors Corporation | Kalamazoo | 1922 |
| DeLorean Motor Company | Detroit | 24 de outubro de 1975 |
| Detroit Diesel | Detroit | 1938 |
| Detroit Electric Car Company | Detroit | 1907 |
| Dodge | Dodge Building | 14 de dezembro de 1900 |
| Excalibur | Milwaukee | 1963 |
| Google driverless car | Mountain View | 13 de dezembro de 2016 |
| Hennessey Performance Engineering | Houston | 1992 |
| Henry Ford Company | Detroit | 1901 |
| Hupmobile | Detroit | 1909 |
| International Harvester | Chicago | 1902 |
| LaSalle | Detroit | 1927 |
| Lincoln | Dearborn | 1917 |
| Marquette | — | 1909 |
| Oldsmobile | Lansing | 1897 |
| Peerless | Cleveland | 1900 |
| Pierce-Arrow | Buffalo | 1870 |
| Polaris Industries | Medina | 1954 |
| Pope Manufacturing Company | Hartford | 1876 |
| Ram Trucks | Auburn Hills | 2010 |
| REO Motor Car Company | Lansing | 1905 |
| Saturn | Spring Hill | 1985 |
| Shelby SuperCars | West Richland | 1999 |
| Stanley Motor Carriage Company | Newton | 1902 |
| Stellantis North America | Chrysler Headquarters and Technology Center | 28 de abril de 2009 |
| Studebaker | South Bend | 1852 |
| Studebaker-Packard Corporation | Detroit | 1954 |
| Thomas Built Buses | High Point | 1972 |
| VLF Automotive | Rochester | 2015 |
| Winton Motor Carriage Company | Cleveland | 1897 |