| OQO | São Francisco | 2000 |
| Paccar | Bellevue | 1905 |
| Packard Bell | Chatsworth | 1926 |
| Padlet | São Francisco | 1 de dezembro de 2012 |
| Palantir Technologies | Miami | 2003 |
| Pantone | Carlstadt | 1962 |
| Parallels | Renton | 1999 |
| Parametric Technology Corporation | Boston | maio 1985 |
| Peet's Coffee | Emeryville | 1966 |
| Pennzoil | Houston | 1963 |
| Philip Morris International | Stamford, Lausana | 1987 |
| Phillips 66 | Westchase | 1 de maio de 2012 |
| Pitney Bowes | Stamford | 1920 |
| PlayStation Now | Aliso Viejo | novembro 2008 |
| Polaris Industries | Medina | 1954 |
| Polycom | São José | 1990 |
| Pony Express | — | 1860 |
| Precision Manuals Development Group | Alexandria | 1997 |
| Providence Equity Partners | 50 Kennedy Plaza | 1989 |
| Qorvo | Greensboro | 2015 |
| Quaker Oats | Chicago | 1877 |
| Quiksilver | Huntington Beach | 1969 |
| Quora | Mountain View | 21 de junho de 2010 |
| R. J. Reynolds Tobacco Company | Winston-Salem | 1874 |
| Ralph Lauren (marca) | Nova Iorque | 1967 |
| Rambus | Sunnyvale | 1990 |
| Rayovac | Middleton | 1906 |
| Re-Logic | Floyds Knobs | 2011 |
| Remington Arms | Madison | 1816 |
| Revlon | Nova Iorque | 1932 |
| Ring of Honor | — | 2002 |
| Rite Aid | Filadélfia, East Pennsboro Township | 1962 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Rohm and Haas | Filadélfia | 1 de setembro de 1909 |
| Roku | Los Gatos | outubro 2002 |
| S&P Global | Rockefeller Center, Nova Iorque | — |
| S. C. Johnson & Son | Racine | 1886 |
| Schlumberger | Houston | 1926 |
| Seagate Technology | Cupertino | 1979 |
| Shelby SuperCars | West Richland | 1999 |
| Sherwin-Williams | Cleveland | 1866 |
| Shutterstock | Nova Iorque, Empire State Building | 2003 |
| Silicon Graphics | Sunnyvale, Mountain View | 9 de novembro de 1981 |
| Silver Lake | Menlo Park | 1999 |
| Six Flags | Arlington | 1961 |
| Six Flags | Charlotte | 1 de julho de 2024 |
| Skechers | Manhattan Beach | 1992 |
| Smith & Wesson | Springfield | 1852 |